One of the most important decisions to be made during the design of a study is the choice of the main endpoint that would best express the effect of interest. It is often the case that several potential suitable main endpoints could be used. Methodology was developed to choose, within a randomized clinical trial, between a relevant endpoint (RE) and a composite endpoint (CE), defined as the union of the relevant and another relevant or secondary endpoint.
Any study exploring specific research questions requires to test well-defined hypotheses that efficiently translate these questions into measurable quantities. To attribute differences in outcomes between two or more groups to their respective different exposure levels, the flagship comparative approach is the randomised clinical trial (RCT).
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