Buil, A.; Martínez-Pérez, A.; Perera, A.; Rib, L.; Soria, J.; Caminal, P. BMC proceedings (Online) Vol. 15, num. 3, p. 1-5 DOI: 10.1186/1753-6561-3-S7-S130 Data de publicació: 2009-12-15 Article en revista
Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis. We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-based test found the PHF19-TRAF1-C5 region. That suggests that no single strategy performs better than another in all cases and that a certain underlying genetic architecture can be delineated more easily with one strategy rather than with another.