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Hydrophobic amino acids at the cytoplasmic ends of helices 3 and 6 of rhodopsin conjointly modulate transducin activation

Autor
Bosch; Iarriccio, L.; Aguilà, M.; Toledo, D.; Ramon, E.; Cordomí, A.; Garriga, P.
Tipus d'activitat
Article en revista
Revista
Archives of biochemistry and biophysics
Data de publicació
2011-02-15
Volum
506
Número
2
Pàgina inicial
142
Pàgina final
149
DOI
https://doi.org/10.1016/j.abb.2010.11.019 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/13237 Obrir en finestra nova
Resum
Rhodopsin is the visual photoreceptor responsible for dim light vision. This receptor is located in the rod cell of the retina and is a prototypical member of the G-protein-coupled receptor superfamily. The structural details underlying the molecular recognition event in transducin activation by photoactivated rhodopsin are of key interest to unravel the molecular mechanism of signal transduction in the retina. We constructed and expressed rhodopsin mutants in the second and third cytoplasmic do...
Citació
Bosch [et al.]. Hydrophobic amino acids at the cytoplasmic ends of helices 3 and 6 of rhodopsin conjointly modulate transducin activation. "Archives of biochemistry and biophysics", 15 Febrer 2011, vol. 506, núm. 2, p. 142-149.
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants

  • Bosch Presegue, Laia  (autor)
  • Iarriccio, Laura  (autor)
  • Aguilà Cerdà, Mònica  (autor)
  • Toledo Gonzalez, Darwin  (autor)
  • Ramon Portés, Eva  (autor)
  • Cordomí Montoya, Arnau  (autor)
  • Garriga Sole, Pere  (autor)