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Binding of a C-end rule peptide to the neuropilin-1 receptor: a molecular modeling approach

Autor
Haspel; Zanuy, D.; Nussinov, R.; Teesalu, T.; Ruoslahti, E.; Aleman, C.
Tipus d'activitat
Article en revista
Revista
Biochemistry
Data de publicació
2011-03-15
Volum
50
Número
10
Pàgina inicial
1755
Pàgina final
1762
DOI
https://doi.org/10.1021/bi101662j Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/13140 Obrir en finestra nova
Resum
Neuropilin-1 (NRP-1) is a receptor that plays an essential role in angiogenesis, vascular permeability, and nervous system development. Previous studies have shown that peptides with an N-terminal Arg, especially peptides with the four-residue consensus sequence R/K/XXR/K, bind to NRP-1 cell surfaces. Peptides containing such consensus sequences promote binding and internalization into cells, while blocking the C-terminal Arg (or Lys) prevents the internalization. In this study, we use molecular...
Citació
Haspel [et al.]. Binding of a C-end rule peptide to the neuropilin-1 receptor: a molecular modeling approach. "Biochemistry", 15 Març 2011, vol. 50, núm. 10, p. 1755-1762.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

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