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Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa

Autor
Bosch; Ramon, E.; Toledo, D.; Cordomi, A.; Garriga, P.
Tipus d'activitat
Article en revista
Revista
The FEBS journal
Data de publicació
2011-05
Volum
278
Número
9
Pàgina inicial
1493
Pàgina final
1505
DOI
https://doi.org/10.1111/j.1742-4658.2011.08066.x Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/13132 Obrir en finestra nova
Resum
The visual photoreceptor rhodopsin undergoes a series of conformational changes upon light activation, eventually leading to the active metarhodopsin II conformation, which is able to bind and activate the G-protein, transducin. We have previously shown that mutant rhodopsins G51V and G89D, associated with retinitis pigmentosa, present photobleaching patterns characterized by the formation of altered photointermediates whose nature remained obscure. Our current detailed UV–visible spectroscopi...
Citació
Bosch [et al.]. Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa. "Febs journal", Maig 2011, vol. 278, núm. 9, p. 1493-1505.
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

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