Carregant...
Carregant...

Vés al contingut (premeu Retorn)

Rational design of new class of BH3-mimetics as inhibitors of the Bcl-X(L) protein

Autor
Pinto, M.; Orzaez , M.; Delgado Soler, L.; Perez, J.; Rubio, J.
Tipus d'activitat
Article en revista
Revista
Journal of chemical information and modeling
Data de publicació
2011-06
Volum
51
Número
6
Pàgina inicial
1249
Pàgina final
1258
DOI
https://doi.org/10.1021/ci100501d Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/13106 Obrir en finestra nova
Resum
The Bcl-2 family of proteins plays an important role in the intrinsic pathway of cell apoptosis. Overexpression of prosurvival members of this family of proteins is often associated with the development of many types of cancer and confers resistance against conventional therapeutic treatments. Accordingly, antagonism of its protective function has emerged as an encouraging anticancer strategy. In the present work, we use a pharmacophore for describing interaction between the BH3 domain of differ...
Citació
Pinto, M. [et al.]. Rational design of new class of BH3-mimetics as inhibitors of the Bcl-X(L) protein. "Journal of chemical information and modeling", Juny 2011, vol. 51, núm. 6, p. 1249-1258.
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
ENGMOL - Enginyeria Molecular
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants

  • Pinto Manresa, Marta  (autor)
  • Orzaez, Maria del Mar  (autor)
  • Delgado Soler, Laura  (autor)
  • Perez Gonzalez, Juan Jesus  (autor)
  • Rubio Martínez, Jaime  (autor)

Arxius