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Enantiomer resolution by pressure increase: inferences from experimental and topological results for the binary enantiomer system (R)- and (S)-mandelic acid

Autor
Rietveld, I.; Del Barrio, M.; Tamarit, J. Ll.; Do, B.; Céolin, R.
Tipus d'activitat
Article en revista
Revista
Journal of physical chemistry B
Data de publicació
2011-11-02
Volum
115
Número
49
Pàgina inicial
14698
Pàgina final
14703
DOI
https://doi.org/10.1021/jp209328d Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/14472 Obrir en finestra nova
URL
http://cataleg.upc.edu/record=b1216643~S1*cat Obrir en finestra nova
Resum
In pharmacy, racemic compounds are often problematic, because generally only one of the enantiomers possesses therapeutic activity and it is often difficult to separate them. Even though this problem is likely as old as the pharmaceutical industry, one thermodynamically obvious way of separating racemic crystals has never been studied experimentally, which is by using pressure. Data have been obtained on the equilibria of the (R)- and (S)-mandelic acid system as a function of pressure and temper...
Citació
Rietveld, I. [et al.]. Enantiomer resolution by pressure increase: inferences from experimental and topological results for the binary enantiomer system (R)- and (S)-mandelic acid. "Journal of physical chemistry B", 02 Novembre 2011, vol. 115, núm. 49, p. 14698-14703.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants