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Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension

Autor
Mahé, N.; Do, B.; Nicolaï, B.; Rietveld, I.; Del Barrio, M.; Tamarit, J. Ll.; Céolin, R.; Ghéchot, C.; Teulon, J.
Tipus d'activitat
Article en revista
Revista
International journal of pharmaceutics
Data de publicació
2012
Volum
422
Número
1-2
Pàgina inicial
47
Pàgina final
51
DOI
https://doi.org/10.1016/j.ijpharm.2011.10.025 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/14578 Obrir en finestra nova
Resum
Aging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference data beyond regulatory considerations. Tienoxolol was studied after 25 years of storage in the dark under ambient conditions. About 86% of the samples still consisted of tienoxolol and the main impurity (13%) was caused by the hydrolysis of the ester moiety. Protection from hu...
Citació
Mahé, N. [et al.]. Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension. "International journal of pharmaceutics", 2012, vol. 422, núm. 1-2, p. 47-51.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants

  • Mahé, Nathalie  (autor)
  • Do, Bernard  (autor)
  • Nicolaï, Béatrice  (autor)
  • Rietveld, Ivo B.  (autor)
  • Del Barrio Casado, Maria  (autor)
  • Tamarit Mur, Jose Luis  (autor)
  • Céolin, René  (autor)
  • Ghéchot, Christophe  (autor)
  • Teulon, Jean-Marie  (autor)