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Inducing functional radial glia-like progenitors from cortical astrocyte cultures using micropatterned PMMA.

Autor
Mattotti, M.; Álvarez, Z.; Ortega, J.; Planell, J. A.; Engel, E.; Alcántara, S.
Tipus d'activitat
Article en revista
Revista
Biomaterials
Data de publicació
2012-02-01
Volum
33
Número
6
Pàgina inicial
1759
Pàgina final
1770
DOI
https://doi.org/10.1016/j.biomaterials.2011.10.086 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/14568 Obrir en finestra nova
Resum
Radial glia cells (RGC) are multipotent progenitors that generate neurons and glia during CNS development, and which also served as substrate for neuronal migration. After a lesion, reactive glia are the main contributor to CNS regenerative blockage, although some reactive astrocytes are also able to dedifferentiate in situ into radial glia-like cells (RGLC), providing beneficial effects in terms of CNS recovery. Thus, the identification of substrate properties that potentiate the ability of ast...
Citació
Mattotti, M. [et al.]. Inducing functional radial glia-like progenitors from cortical astrocyte cultures using micropatterned PMMA.. "Biomaterials", 01 Febrer 2012, vol. 33, núm. 6, p. 1759-1770.
Paraules clau
Astrocyte, Co-culture, Micropatterning, Nerve Guide, Polymethylmethacrylate, Surface Topography
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica

Participants