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Pressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior

Autor
Del Barrio, M.; Maccaroni, E.; Rietveld, I.; Macpezzi, L.; Masciocchi, N.; Céolin, R.; Tamarit, J. Ll.
Tipus d'activitat
Article en revista
Revista
Journal of pharmaceutical sciences
Data de publicació
2012-03
Volum
101
Número
3
Pàgina inicial
1072
Pàgina final
1078
DOI
https://doi.org/10.1002/jps.22821 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/14696 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/jps.22821/pdf Obrir en finestra nova
Resum
The active pharmaceutical ingredient racemic benfluorex hydrochloride (benfluorex–HCl) has an interesting phase behavior due to an elusive solid–solid phase transition. The stability hierarchy between different phases is often determined based on heat-related experiments only or slurry interconversion. It is shown that if pressure and volume are taken into account, not only the phase equilibria are correctly positioned in the pressure–temperature phase diagram, but the experimental data al...
Citació
Del Barrio, M. [et al.]. Pressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior. "Journal of pharmaceutical sciences", 03 Novembre 2011, vol. 101, núm. 3, p. 1072-1078.
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants