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Preparation of biodegradable polylactide microparticles via a biocompatible procedure

Autor
Levato, R.; Mateos, M.; Planell, J. A.
Tipus d'activitat
Article en revista
Revista
Macromolecular bioscience
Data de publicació
2012-04
Volum
12
Número
4
Pàgina inicial
557
Pàgina final
566
DOI
https://doi.org/10.1002/mabi.201100383 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/16504 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201100383/pdf Obrir en finestra nova
Resum
PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 mm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green sol...
Citació
Levato, R.; Mateos, M.; Planell, J. Preparation of biodegradable polylactide microparticles via a biocompatible procedure. "Macromolecular bioscience", Abril 2012, vol. 12, núm. 4, p. 557-566.
Paraules clau
Biocompatibility, Biodegradable, Green solvents, Microparticles, Poly(lactic acid)
Grup de recerca
CREB - Centre de Recerca en Enginyeria Biomedica
IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants