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Crystal structure of a complex of DNA with one AT-hook of HMGA1

Author
Fonfria, E.; Acosta, F.J.; Saperas, N.; Pous, J.; Subirana, J.; Campos, J.Lourdes
Type of activity
Journal article
Journal
PloS one
Date of publication
2012-05-16
Volume
7
Number
5
First page
1
Last page
5
DOI
https://doi.org/10.1371/journal.pone.0037120 Open in new window
Repository
http://hdl.handle.net/2117/16654 Open in new window
URL
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037120 Open in new window
Abstract
We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)2, which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT-hook forms hydrogen bonds between main-chain NH groups and thymines in the minor groove, DNA is bent and...
Citation
Fonfria, E. [et al.]. Crystal structure of a complex of DNA with one AT-hook of HMGA1. "PLoS One", 16 Maig 2012, vol. 7, núm. 5, p. 1-5.
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

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