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Network-based enrichment analysis of gene expression through protein-protein interaction data

Author
Massanet, R.; Fernandez, F.; Perera, A.; Caminal, P.
Type of activity
Presentation of work at congresses
Name of edition
34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Date of publication
2012
Presentation's date
2012-09-01
Book of congress proceedings
Annual international conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2012 : San Diego, California, USA, Aug. 28-1Sept. 1, 2012
First page
6317
Last page
6320
Publisher
IEEE
DOI
https://doi.org/10.1109/EMBC.2012.6347438 Open in new window
Repository
http://hdl.handle.net/2117/17221 Open in new window
Abstract
High-throughput analysis of gene expression data is subject to technological and statistical issues that confuse the underlying expression-condition associations. In this contribution a network-based candidate gene prioritization strategy was applied to the enrichment of a publicly available gene expression dataset, focused on the study of the mechanosensitivity of genes exposed to altered pulmonary matrix stiffness. Results suggested that some genes which had not been taken into account in the ...
Citation
Massanet, R. [et al.]. Network-based enrichment analysis of gene expression through protein-protein interaction data. A: IEEE Engineering in Medicine and Biology Society. "34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August-1 September, 2012". San Diego, California: IEEE, 2012, p. 6317-6320.
Group of research
B2SLab - Bioinformatics and Biomedical Signals Laboratory
CREB - Biomedical Engineering Research Centre

Participants