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Effect of thiol-functionalisation on chitosan antibacterial activity: interaction with a bacterial membrane model

Autor
Macedo, M.M.; Francesko, A.; Torrent, J.; Torrent-Burgués, J.; Tzanov, T.
Tipus d'activitat
Article en revista
Revista
Reactive and functional polymers
Data de publicació
2013-01-12
Volum
73
Número
10
Pàgina inicial
2013
Pàgina final
1384
DOI
https://doi.org/10.1016/j.reactfunctpolym.2013.01.004 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22395 Obrir en finestra nova
URL
http://dx.doi.org/10.1016/j.reactfunctpolym.2013.01.004 Obrir en finestra nova
Resum
The antibacterial activity of chitosan modified with the thiol-containing 2-iminothiolane HCl (TC-IMI) and N-acetyl- L -cysteine (TC-NAC) was studied by Langmuir film balance technique using a dipalmitoylphos- phatidylglycerol (DPPG) monolayer bacterial membrane model. The interactions of the biopolymer with the membrane model were assessed by monitoring the differences in the shape of the compression iso- therms recorded in the absence and presence of chitosan and thiolated conjugates in the su...
Citació
Macedo, M.M. [et al.]. Effect of thiol-functionalisation on chitosan antibacterial activity: interaction with a bacterial membrane model. "Reactive and functional polymers", 12 Gener 2013, vol. 73, núm. 10, p. 2013-1384.
Paraules clau
Antibacterial activity, Cell membrane mode, Langmuir monolayers, Thiolated chitosan
Grup de recerca
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants