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Effects of ring contraction on the conformational preferences of a-substituted proline analogs

Author
Revilla-López, G.; Warren, J.G.; Torras, J.; Jimenez, A.; Cativiela, C.; Aleman, C.
Type of activity
Journal article
Journal
Biopolymers
Date of publication
2012-03-01
Volume
98
Number
2
First page
98
Last page
110
DOI
https://doi.org/10.1002/bip.21716 Open in new window
Repository
http://hdl.handle.net/2117/17488 Open in new window
URL
http://onlinelibrary.wiley.com/doi/10.1002/bip.21716/abstract Open in new window
Abstract
The structural consequences derived from the incorporation of either a methyl or a phenyl group at the a carbon of proline were recently investigated by quantum mechanical calculations (J Org Chem 2008, 73, 3418). In this work, the effect produced by contraction of the pyrrolidine ring on such a-substituted proline analogs has been explored using the same computational methods. Specifically, the intrinsic conformational preferences of the N-acetyl-N 0 -methylamide derivatives of the lower prolin...
Citation
Revilla-López, G. [et al.]. Effects of ring contraction on the conformational preferences of a-substituted proline analogs. "Biopolymers", 01 Març 2012, vol. 98, núm. 2, p. 98-110.
Group of research
CRnE - Barcelona Research Center in Multiscale Science and Engineering
IMEM-BRT - Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies

Participants