Loading...
Loading...

Go to the content (press return)

Dependency of calcium alternans on ryanodine receptor refractoriness

Author
Alvarez-Lacalle, E.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Cinca, J.; Hove-Madsen, L.; Echebarria, B.
Type of activity
Journal article
Journal
PloS one
Date of publication
2013-02-04
Volume
8
Number
2
DOI
https://doi.org/10.1371/journal.pone.0055042 Open in new window
Repository
http://hdl.handle.net/2117/18961 Open in new window
URL
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055042 Open in new window
Abstract
Background Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium released from the sarcoplasmic reticulum (SR). However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) remains elusive. Methodology/Principal Findings To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis using a numerical rabbit cardiomyocyte model. We used a m...
Citation
Alvarez-Lacalle, E. [et al.]. Dependency of calcium alternans on Ryanodine Receptor Refractoriness. "PLoS One", 04 Febrer 2013, vol. 8, núm. 2.
Keywords
EMTREE drug terms: ryanodine receptor 2 EMTREE medical terms: article, beat to beat calcium response, calcium cell level, calcium current, calcium loading, calcium signaling, calcium transport, channel gating, chemical parameters, computer model, controlled study, cytosolic calcium alternans, heart muscle cell, mathematical model, molecular dynamics, nonhuman, predictive value, rabbit, receptor activation, receptor inactivation, receptor refractoriness, sarcoplasmic reticulum, validation process
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

Participants