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Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes

Author
Barriga, M.; Cal, R.; Cabello, N.; Llach, A.; Vallmitjana, A.; Benitez, R.; Badimon, L.; Llorente-Cortés, V.; Cinca, J.; Hove-Madsen, L.
Type of activity
Journal article
Journal
PloS one
Date of publication
2013-03-13
Volume
8
Number
3
First page
1
Last page
10
DOI
https://doi.org/10.1371/journal.pone.0058128 Open in new window
Project funding
DESARROLLO DE TÉCNICAS DE ANÁLISIS DE SITEMAS COMPLEJOS PARA EL ESTUDIO DE PROBLEMAS EN FISIOLOGÍA CARDÍACA
Repository
http://hdl.handle.net/2117/18515 Open in new window
URL
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058128 Open in new window
Abstract
The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects on cardiomyocyte function. We therefore aimed at testing the hypothesis that Low Density Lipoprotein (LDL) cholesterol affects calcium dynamics and signal propagation in cultured atrial myocytes. For this purpose, mRNA and protein expression levels were determined by real time PCR and western blot analysis, respectively, and intracellular c...
Citation
Barriga, M. [et al.]. Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes. "PLoS One", 13 Març 2013, vol. 8, núm. 3.
Keywords
ARRHYTHMIAS, HUMAN ATRIAL-FIBRILLATION, JUNCTIONS, MYOCYTES, PROTEIN, RECEPTORS, SARCOPLASMIC-RETICULUM, SIMVASTATIN, SMOOTH-MUSCLE-CELLS, VENTRICULAR-FIBRILLATION
Group of research
ANCORA - Anàlisi i control del ritme cardíac
CREB - Biomedical Engineering Research Centre

Participants

  • Barriga, Montserrat  (author)
  • Cal, Roi  (author)
  • Cabello, Núria  (author)
  • Llach, Anna  (author)
  • Vallmitjana Lees, Alexander  (author)
  • Benitez Iglesias, Raul  (author)
  • Badimon, Lina  (author)
  • Llorente Cortés, Vicenta  (author)
  • Cinca Cuscullola, Juan Maria  (author)
  • Hove-Madsen, Leif  (author)

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