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Some theoretical thoughts when using a composite endpoint to prove the efficacy of a treatment

Autor
Gómez Melis, Guadalupe
Tipus d'activitat
Presentació treball a congrés
Nom de l'edició
26th International Workshop on Statistical Modelling
Any de l'edició
2011
Data de presentació
2011-07
Llibre d'actes
Proceedings of the 26th International Workshop on Statistical Modelling
Pàgina inicial
14
Pàgina final
21
Repositori
http://hdl.handle.net/2117/22571 Obrir en finestra nova
Resum
This paper discusses, following Gómez and Lagakos (2011) methodology, to what extent is there a gain in efficiency from adding a component event to a relevant endpoint when the treatment effect on this component is not as strong as on the original relevant endpoint under ideal (independence) circumstances. It presents the bivariate copula model used to overcome the independence assumption and presents the relationship between the components of the asymptotic relative efficiency and a set of int...
Citació
Gómez, G. Some theoretical thoughts when using a composite endpoint to prove the efficacy of a treatment. A: International Workshop on Statistical Modelling. "Proceedings of the 26th International Workshop on Statistical Modelling". València: 2011, p. 14-21.
Paraules clau
Asymptotic Relative Efficiency, Composite Endpoints, Composite Outcomes, Copula Model, Logrank tests Els codis AMS escollits són: 62N01 Statistics: Survival analysis and sensored data: Censored data models i 62N02 Statistics: Survival analysis and censored data: Estimation
Grup de recerca
GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica

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