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Some theoretical thoughts when using a composite endpoint to prove the efficacy of a treatment

Author
Gómez Melis, Guadalupe
Type of activity
Presentation of work at congresses
Name of edition
26th International Workshop on Statistical Modelling
Date of publication
2011
Presentation's date
2011-07
Book of congress proceedings
Proceedings of the 26th International Workshop on Statistical Modelling
First page
14
Last page
21
Repository
http://hdl.handle.net/2117/22571 Open in new window
Abstract
This paper discusses, following Gómez and Lagakos (2011) methodology, to what extent is there a gain in efficiency from adding a component event to a relevant endpoint when the treatment effect on this component is not as strong as on the original relevant endpoint under ideal (independence) circumstances. It presents the bivariate copula model used to overcome the independence assumption and presents the relationship between the components of the asymptotic relative efficiency and a set of int...
Citation
Gómez, G. Some theoretical thoughts when using a composite endpoint to prove the efficacy of a treatment. A: International Workshop on Statistical Modelling. "Proceedings of the 26th International Workshop on Statistical Modelling". València: 2011, p. 14-21.
Keywords
Asymptotic Relative Efficiency, Composite Endpoints, Composite Outcomes, Copula Model, Logrank tests Els codis AMS escollits són: 62N01 Statistics: Survival analysis and sensored data: Censored data models i 62N02 Statistics: Survival analysis and censored data: Estimation
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

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