Loading...
Loading...

Go to the content (press return)

Improved Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin by Specific Interaction with Docosahexaenoic Acid Phospholipid

Author
Sanchez, M.; Ramon, E.; Torrent-Burgués, J.; Garriga, P.
Type of activity
Journal article
Journal
Chembiochem
Date of publication
2013-03
Volume
14
Number
5
First page
639
Last page
644
DOI
https://doi.org/10.1002/cbic.201200687 Open in new window
Abstract
Rhodopsin is the photoreceptor located in the rod cells of the retina. It has seven transmembrane helices and is a prototypic member of the G protein-coupled receptor superfamily. The structures and functions of these receptors are clearly affected by the lipid composition of the cell membrane, and their study in a purified recombinant form is usually performed in detergent solution. There is a need to study these receptors in a physiologically relevant environment because the lipid environment ...
Keywords
Adsorption isotherm, Fluorescence spectroscopy, Insertion into lipid monolayers, Liposomes, Phospholipids, Rhodopsin
Group of research
CEBIM - Molecular Biotechnology Centre
GBMI - Molecular and Industrial Biotechnology Group

Participants