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Advances in semi-supervised alignment-free classification of G protein-coupled receptors

Author
Vellido, A.; Cruz, R.; Giraldo, J.
Type of activity
Presentation of work at congresses
Name of edition
2013 - International Work-Conference on Bioinformatics and Biomedical Engineering
Date of publication
2013
Presentation's date
2013-03
Book of congress proceedings
Proceedings of the International Work-Conference on Bioinformatics and Biomedical Engineering 2013
First page
759
Last page
766
Repository
http://hdl.handle.net/2117/20417 Open in new window
URL
http://iwbbio.ugr.es/papers/iwbbio_121.pdf Open in new window
Abstract
G Protein-coupled receptors (GPCRs) are integral cell membrane proteins of great relevance for pharmacology due to their role in transducing extracellular signals. The 3-D s tructure is unknown for most of them, and the investigation of their structure-function relationships usually relies on the construction of 3-D receptor models from amino acid sequence alignment onto those receptors of known structure. Sequence alignment risks the loss of relevant information. Different approaches have attem...
Citation
Cruz, R.; Vellido, A.; Giraldo, Jesús. Advances in semi-supervised alignment-free classification of G protein-coupled receptors. A: International Work-Conference on Bioinformatics and Biomedical Engineering. "Proceedings of the International Work-Conference on Bioinformatics and Biomedical Engineering 2013". Granada: 2013, p. 759-766.
Keywords
QSAR, biology computing, biomembranes, cellular biophysics, covariance analysis, molecular biophysics, proteins
Group of research
IDEAI-UPC - Intelligent Data Science and Artificial Intelligence Research Center
SOCO - Soft Computing

Participants

  • Vellido Alcacena, Alfredo  (author and speaker )
  • Cruz Barbosa, Raúl  (author and speaker )
  • Giraldo Arjonilla, Jesús  (author and speaker )

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