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Circuit-level input integration in bacterial gene regulation

Autor
Espinar, M.; Dies, M.; Garcia, J.; Cagatay, T.; Süel, G.
Tipus d'activitat
Article en revista
Revista
Proceedings of the National Academy of Sciences of the United States of America
Data de publicació
2013-04
Volum
110
Número
17
Pàgina inicial
7091
Pàgina final
7096
DOI
https://doi.org/10.1073/pnas.1216091110 Obrir en finestra nova
Resum
Gene regulatory circuits can receive multiple simultaneous inputs, which can enter the system through different locations. It is thus necessary to establish how these genetic circuits integrate multiple inputs as a function of their relative entry points. Here, we use the dynamic circuit regulating competence for DNA uptake in Bacillus subtilis as a model system to investigate this issue. Specifically, we map the response of single cells in vivo to a combination of (i) a chemical signal controll...
Paraules clau
bistability, excitability, genetic competence, genetic oscillations, signal integration
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
DONLL - Dinàmica no Lineal, Òptica no Lineal i Làsers

Participants

  • Espinar Calvo, Maria Lorena  (autor)
  • Dies Miracle, Marta  (autor)
  • Garcia Ojalvo, Jorge  (autor)
  • Cagatay, Tolga  (autor)
  • Süel, Gürol M.  (autor)