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Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice

Author
Bai, Y.; Jones, P.; Guo, J.; Zhong, X.; Clark, R.; Zhou, Q.; Wang, R.; Vallmitjana, A.; Benitez, R.; Hove-Madsen, L.; Semeniuk, L.; Guo, A.; Song, L.; Duff, H.J.; Wayne Chen, S. R.
Type of activity
Journal article
Journal
Circulation research
Date of publication
2013-07-15
Volume
113
First page
517
Last page
526
DOI
https://doi.org/10.1161/CIRCRESAHA.113.301678 Open in new window
Project funding
Aplicación de técnicas de análisis de sistemas complejos al estudio de problemas de fisiología cardíaca
Repository
http://hdl.handle.net/2117/20251 Open in new window
URL
http://circres.ahajournals.org/content/113/5/517.full.html?ijkey=3DrZZXugzNwB6kn&keytype=ref Open in new window
Abstract
Rationale: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca2+ ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca2+ load and Ca2+ leak. Conversely, PLN-KO accelerates Ca2+ sequestration and aborts arrhythmogenic spontaneous Ca2+ waves (SCWs). An important question is whether these seemingly paradoxical effects of PLN-KO exacerbate or protect against Ca2+-triggered arrhythmias. Objective: We investigate the impact of PLN-KO on SCWs, triggered activities,...
Citation
Bai, Y. [et al.]. Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. "Circulation research", 15 Juliol 2013, vol. 113, p. 517-526.
Keywords
Calcium handling, Cardiac dynamics, biomedical signal processing, quantitative physiology
Group of research
ANCORA - Anàlisi i control del ritme cardíac
CREB - Biomedical Engineering Research Centre

Participants

  • Bai, Yunlong  (author)
  • Jones, Peter  (author)
  • Guo, Jiqing  (author)
  • Zhong, Xiaowei  (author)
  • Clark, Robert  (author)
  • Zhou, Qiang  (author)
  • Wang, Ruiwu  (author)
  • Vallmitjana Lees, Alexander  (author)
  • Benitez Iglesias, Raul  (author)
  • Hove-Madsen, Leif  (author)
  • Semeniuk, Lisa  (author)
  • Guo, Ang  (author)
  • Song, Long-Sheng  (author)
  • Duff, Henry J.  (author)
  • Chen, S. R. Wayne  (author)