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Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres

Autor
Rodriguez, A.; Canal, C.; Calafell, M.; Ginebra, M.P.; Julio, G.; Marques, M.S.
Tipus d'activitat
Article en revista
Revista
European polymer journal
Data de publicació
2013-11
Volum
49
Número
11
Pàgina inicial
3501
Pàgina final
3511
DOI
https://doi.org/10.1016/j.eurpolymj.2013.08.010 Obrir en finestra nova
Projecte finançador
BIOMATERIALES CON PROPIEDADES ANTIMICROBIANAS Y DE REGENERACIÓN OSEA PARA CIRUGIA ORAL Y MAXILOFACIAL
Repositori
http://hdl.handle.net/2117/20562 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0014305713004205 Obrir en finestra nova
Resum
Natural and synthetic biodegradable polymers have been investigated for controlled drug release. Poly(3-hydroxybutyrate) can be produced by bacteria and is remarkable for this application due to its excellent biocompatibility and biodegradability. The objective of this work was to study different drug-entrapment and emulsification methods for the obtaining of doxycycline-loaded PHB micro- and nano-spheres. The micro-/nano-particles were prepared by polymer precipitation via dialysis, simple emul...
Citació
Rodriguez, A. [et al.]. Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres. "European polymer journal", Novembre 2013, vol. 49, núm. 11, p. 3501-3511.
Paraules clau
Doxycycline, Drug delivery systems, Micro- and nano-particles, Poly(3-hydroxybutirate)
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CEBIM - Centre de Biotecnologia Molecular
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
Càtedra A3 - Càtedra A3
TMAS (T+) - Toxicologia i Microbiologia Ambiental i Sanitària

Participants