Surface properties of biomaterials play a major role in the governing of cell
functionalities. It is well known that mechanical, chemical and nanotopo-
graphic cues, for example, influence cell proliferation and differentiation.
Here, we present a novel coating protocol to produce hierarchicallyengineered
fibrous scaffolds with tailorable surface characteristics, which mimic bone
extracellular matrix. Based on the sol–gel method and a succession of surface
treatments, hollow electrospun polyla...