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Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III

Autor
Gana, I.; Del Barrio, M.; Do, B.; Tamarit, J. Ll.; Céolin, R.; Rietveld, I.
Tipus d'activitat
Article en revista
Revista
International journal of pharmaceutics
Data de publicació
2013-11-18
Volum
456
Número
2
Pàgina inicial
480
Pàgina final
488
DOI
https://doi.org/10.1016/j.ijpharm.2013.08.031 Obrir en finestra nova
Projecte finançador
Dinámica en sólidos desordenados
TRANSICIONS DE FASES, POLIMORFISME I DINÀMICA DE LA METAESTABILITAT
Repositori
http://hdl.handle.net/2117/21276 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0378517313007643 Obrir en finestra nova
Resum
Understanding the phase behavior of an active pharmaceutical ingredient in a drug formulation is required to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in a marketed product. Benzocaine is known to possess three crystalline polymorphs, but their stability hierarchy has so far not been determined. A topological method and direct calorimetric measurements under pressure have been used to construct the topological pressure-temperature diagram of the phase ...
Citació
Gana, I. [et al.]. Benzocaine polymorphism: Pressure-temperature phase diagram involving forms II and III. "International journal of pharmaceutics", 18 Novembre 2013, vol. 456, núm. 2, p. 480-488.
Paraules clau
Phase diagram, Physical stability, Polymorphism, Pressure, Thermodynamics, X-ray powder diffraction
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona
GCM - Grup de Caracterització de Materials

Participants