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Early but limited effects of raltegravir intensification on CD4 T cell reconstitution in HIV-infected patients with an immunodiscordant response to antiretroviral therapy

Author
Negredo, E.; Massanella, M.; Puertas, M.; Buzon, M.; Perez, N.; Puig, J.; Pérez, J.; Bonjoch, A.; Molto, J.; Jou, A.; Echevarría, P.; Llibre, J.M.; Martínez, J.; Clotet, B.; Blanco, J.
Type of activity
Journal article
Journal
Journal of antimicrobial chemotherapy
Date of publication
2013-10
Volume
68
Number
10
First page
2358
Last page
2362
DOI
https://doi.org/10.1093/jac/dkt183 Open in new window
Abstract
Background:Immune hyperactivation in immunodiscordant patients can induce residual HIV replication and limit CD4Tcell recovery. We assessed theimpact of raltegravir intensification onCD4 T cell recoveryandviral persistence.Methods: We performed a randomized, controlled, pilot trial. Patients with CD4 T cell counts <350 cells/mm3 despite suppressive antiretroviral therapy were randomized (2:1) to intensify with raltegravir (intensified arm, n=30) or to continue with the same regimen (control arm,...
Keywords
Discordant patients, Immune recovery, Integrase inhibitor, Viral suppression
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Negredo Puigmal, Eugènia  (author)
  • Massanella, Marta  (author)
  • Puertas Castro, Maria C.  (author)
  • Buzon, Maria José  (author)
  • Perez Alvarez, Nuria  (author)
  • Puig Domingo, Jordi  (author)
  • Pérez Santiago, Josué  (author)
  • Bonjoch Badia, Anna  (author)
  • Molto Marhuenda, Jose  (author)
  • Jou, Antoni  (author)
  • Echevarría, Patricia  (author)
  • Llibre, Josep M.  (author)
  • Martínez Picado, Javier  (author)
  • Clotet Sala, Bonaventura  (author)
  • Blanco, Julia  (author)