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Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist.

Autor
Knappe, T.A.; Manzenrieder, F.; Mas-Moruno, C.; Linne, U.; Sasse, F.; Kessler, H.; Xie, X.; Marahiel, M.A.
Tipus d'activitat
Article en revista
Revista
Angewandte chemie. International edition
Data de publicació
2011
Volum
50
Número
37
Pàgina inicial
8714
Pàgina final
8717
DOI
https://doi.org/10.1002/anie.201102190 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22784 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/anie.201102190/abstract Obrir en finestra nova
Resum
Thumbnail image of graphical abstract Tightening the noose: Lasso peptides are a class of stable bacterial peptides with unique characteristics that encourage their application in drug design. Epitope grafting of the integrin binding motif RGD onto the lasso structure of microcin J25 converts the knotted peptide into a nanomolar integrin antagonist (see picture). Engineered lasso peptides can therefore be used for pharmacophore presentation.
Citació
Knappe, T.A. [et al.]. Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist.. "Angewandte chemie. International edition", 2011, vol. 50, núm. 37, p. 8714-8717.
Paraules clau
drug design, epitope grafting, integrin inhibitors, lasso peptides, molecular scaffolds
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Knappe, T.A.  (autor)
  • Manzenrieder, Florian  (autor)
  • Mas Moruno, Carlos  (autor)
  • Linne, U.  (autor)
  • Sasse, F.  (autor)
  • Kessler, Horst  (autor)
  • Xie, X.  (autor)
  • Marahiel, M.A.  (autor)