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Nanostructure formation enhances the activity of LPS-neutralizing peptides

Autor
Mas-Moruno, C.; Cascales, L.; Cruz, L.J.; Mora, P.; Perez, E.; Albericio, F.
Tipus d'activitat
Article en revista
Revista
Chemmedchem
Data de publicació
2008
Volum
3
Número
11
Pàgina inicial
1748
Pàgina final
1755
DOI
https://doi.org/10.1002/cmdc.200800209 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/22806 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.200800209/pdf Obrir en finestra nova
Resum
Peptides that interact with lipopolysaccharide (LPS) can provide the basis for the development of new antisepsis agents. In this work, several LPS-neutralizing acyl peptides derived from LALF, BPI, and SAP were prepared, structurally characterized, and biologically evaluated. In all cases, peptides with long acyl chains showed greater LPS-neutralizing activities than the original acetylated peptides. Structural analysis of these peptides revealed that N-acylation with long acyl chains promotes t...
Citació
Mas-Moruno, C. [et al.]. Nanostructure formation enhances the activity of LPS-neutralizing peptides. "Chemmedchem", 2008, vol. 3, núm. 11, p. 1748-1755.
Paraules clau
biological activity, drug design, lipopeptides, medicinal chemistry, structure–activity relationships
Grup de recerca
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Mas Moruno, Carlos  (autor)
  • Cascales, Laura  (autor)
  • Cruz, Luis Javier  (autor)
  • Mora, Pablo  (autor)
  • Perez Paya, Enrique  (autor)
  • Albericio Palomera, Fernando  (autor)