Loading...
Loading...

Go to the content (press return)

Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model

Author
Lugo, C.A.; Rodriguez Cantalapiedra, I.; Peñaranda, A.; Hove-Madsen, L.; Echebarria, B.
Type of activity
Journal article
Journal
American journal of physiology. Heart and circulatory physiology
Date of publication
2014-06-01
Volume
306
Number
11
First page
H1540
Last page
H1552
DOI
https://doi.org/10.1152/ajpheart.00515.2013 Open in new window
Repository
http://hdl.handle.net/2117/23521 Open in new window
Abstract
Despite the important role of electromechanical alternans in cardiac arrhythmogenesis, its molecular origin is not well understood. The appearance of calcium alternans has often been associated to fluctuations in the sarcoplasmic reticulum (SR) Ca loading. However, cytosolic calcium alternans observed without concurrent oscillations in the SR Ca content suggests an alternative mechanism related to a dysfunction in the dynamics of the ryanodine receptor (RyR2). We have investigated the effect of ...
Citation
Lugo, C.A. [et al.]. Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model. "American journal of physiology. Heart and circulatory physiology", 01 Juny 2014, vol. 306, núm. 11, p. H1540-H1552.
Keywords
CALCIUM, CONTRACTION, FIBRILLATION, HEART-FAILURE, MATHEMATICAL-MODEL, RELEASE, REPOLARIZATION ALTERNANS, SARCOPLASMIC-RETICULUM, SR calcium release refractoriness, T-TUBULES, VENTRICULAR MYOCYTES, arrhythmias, calcium dynamics, electromechanical alternans, ryanodine receptor
Group of research
ANCORA - Anàlisi i control del ritme cardíac
BIOCOM-SC - Computational Biology and Complex Systems Group
GICITED - Interdisciplinary Group on Building Scienceand and Technology

Participants