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In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27

Author
Acosta, F.J.; Dardonville, C.; De Koning, H.; Natto, M.; Subirana, J.; Campos, J.Lourdes
Type of activity
Journal article
Journal
Acta crystallographica section D: Biological crystallography
Date of publication
2014-06
Volume
70
Number
6
First page
1614
Last page
1621
DOI
https://doi.org/10.1107/S139900471400697X Open in new window
Repository
http://hdl.handle.net/2117/23505 Open in new window
URL
http://scripts.iucr.org/cgi-bin/paper?S139900471400697X Open in new window
Abstract
The DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum and the causative agents of trichomoniasis and trypanosomiases. This fact has prompted studies of drugs which interact with the minor groove of DNA, some of which are used in medical practice. Previous studies have been performed almost exclusively with the AATT sequence. New features should be uncovered through the study of different DNA sequences. In this paper, the c...
Citation
Acosta, F.J. [et al.]. In and out of the minor groove: Interaction of an AT-rich DNA with the drug CD27. "Acta Crystallographica Section D: Biological Crystallography", Juny 2014, vol. 70, núm. 6, p. 1614-1621.
Keywords
AT-rich DNA, CD27, d(AAAATTTT, minor-groove binding drug
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

Participants

  • Acosta Reyes, Francisco Javier  (author)
  • Dardonville, Cristophe Y.  (author)
  • De Koning, Harry Pieter  (author)
  • Natto, Manal J.  (author)
  • Subirana, Juan Antonio  (author)
  • Campos Lopez, Josefa de Lourdes  (author)

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