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One-step sonochemical preparation of redox-responsive nanocapsules for glutathione mediated RNA release

Autor
Francesko, A.; Macedo, M.M.; Tzanov, T.; Perelshtein, I.; Gedanken, A.; Benisvy , L.
Tipus d'activitat
Article en revista
Revista
Journal of materials chemistry B
Data de publicació
2014-07-09
Volum
2
Número
36
Pàgina inicial
6020
Pàgina final
6029
DOI
https://doi.org/10.1039/c4tb00599f Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/23597 Obrir en finestra nova
URL
http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB00599F#!divAbstract Obrir en finestra nova
Resum
Efficient RNA delivery to targeted cells requires the use of stable interactive carriers that provide RNA protection during the extracellular transit and trigger release once internalised. One strategy to avoid the premature extracellular RNA drain coupled to sufficient intracellular release is the use of stimuli-responsive delivery materials exploiting as a triggering mechanism the redox gradient between the extra- and intracellular compartments. This work describes a facile route for preparati...
Citació
Francesko, A. [et al.]. One-step sonochemical preparation of redox-responsive nanocapsules for glutathione mediated RNA release. "Journal of materials chemistry B", 09 Juliol 2014, p. 1-27.
Paraules clau
CELL, CHITOSAN MICROSPHERES, GENE DELIVERY, IN-VITRO EVALUATION, INTRACELLULAR DRUG-DELIVERY, MACROMOLECULES, MICROPARTICLES, NANOPARTICLES, PROTEINACEOUS MICROSPHERES, SYSTEMS
Grup de recerca
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants

  • Francesko, Antonio  (autor)
  • Macedo Fernandes, Margarida Maria  (autor)
  • Tzanov, Tzanko  (autor)
  • Perelshtein, Ilana  (autor)
  • Gedanken, Aharon  (autor)
  • Benisvy Aharonovich, Lena  (autor)