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Mercury-induced dark-state instability and photobleaching alterations of the visual G-protein coupled receptor rhodopsin

Autor
Morillo, M.; Toledo, D.; Perez, J.; Ramon, E.; Garriga, P.
Tipus d'activitat
Article en revista
Revista
Chemical research in toxicology
Data de publicació
2014-07-01
Volum
27
Número
7
Pàgina inicial
1219
Pàgina final
1226
DOI
https://doi.org/10.1021/tx500114s Obrir en finestra nova
Projecte finançador
ALTERACIONES PROCESOS ACTIVACION Y TRANSDUCCION DE SEÑAL DE RECEPTORES ACOPLADOS A PROTEINAS G
GRUP DE BIOTECNOLOGIA MOL.LECULAR I INDUSTRIAL
Repositori
http://hdl.handle.net/2117/24291 Obrir en finestra nova
URL
http://pubs.acs.org/doi/pdf/10.1021/tx500114s Obrir en finestra nova
Resum
Mercuric compounds were previously shown to affect the visual phototransduction cascade, and this could result in vision impairment. We have analyzed the effect of mercuric chloride on the structure and stability of the dim light vision photoreceptor rhodopsin. For this purpose, we have used both native rhodopsin imrnunopurified from bovine retinas and a recombinant mutant rhodopsin carrying several Cys to Ser substitutions in order to investigate the potential binding site of mercury on the rec...
Citació
Morillo, M. [et al.]. Mercury-induced dark-state instability and photobleaching alterations of the visual G-protein coupled receptor rhodopsin. "Chemical research in toxicology", 01 Juliol 2014, vol. 27, núm. 7, p. 1219-1226.
Paraules clau
Accumulation, Activation, Color-vision, Conformational stability, Crystal-structure, Molecular-mechanisms, Organic mercurial, Retinitis-pigmentosa, Thermal-stability, Workers
Grup de recerca
CEBIM - Centre de Biotecnologia Molecular
ENGMOL - Enginyeria Molecular
GBMI - Grup de Biotecnologia Molecular i Industrial

Participants