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Nanoparticles of esterified polymalic acid for controlled anticancer drug release

Autor
Lanz, A.; Martinez de Ilarduya, A.; Portilla, J.A.; Garcia, M.; Holler, E.; Ljubimova, J.; Muñoz, S.
Tipus d'activitat
Article en revista
Revista
Macromolecular bioscience
Data de publicació
2014-09-01
Volum
14
Número
9
Pàgina inicial
1325
Pàgina final
1336
DOI
https://doi.org/10.1002/mabi.201400124 Obrir en finestra nova
Projecte finançador
Bioplásticos derivados de carbohidratos para envasado y farmacia. Subproyecto II.
Repositori
http://hdl.handle.net/2117/24073 Obrir en finestra nova
URL
http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400124/abstract Obrir en finestra nova
Resum
Esterification of microbial poly(malic acid) is performed with either ethanol or 1-butanol to obtain polymalate conjugates capable to form nanoparticles (100–350 nm). Degradation under physiological conditions takes place with release of malic acid and the corresponding alcohol as unique degradation products. The anticancer drugs Temozolomide and Doxorubicin are encapsulated in nanoparticles with efficiency of 17 and 37%, respectively. In vitro drug release assays show that Temozolomide is alm...
Citació
Lanz, A. [et al.]. Nanoparticles of esterified polymalic acid for controlled anticancer drug release. "Macromolecular bioscience", 01 Setembre 2014, vol. 14, núm. 9, p. 1325-1336.
Paraules clau
biodegradable drug delivery systems, poly(malic acid), poly(malic acid) nanoparticles
Grup de recerca
POL - Polímers Industrials Avançats i Biopolímers Tecnològics

Participants