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Interplay of packing and flip-flop in local bilayer deformation. How phosphatidylglycerol could rescue mitochondrial function in a cardiolipin-deficient yeast mutant

Autor
Khalifat, N.; Rahimi, M.; Bitbol, A.; Seigneuret, M.; Fournier, Jean-baptiste; Puff, N.; Arroyo, M.; Angelova, M.
Tipus d'activitat
Article en revista
Revista
Biophysical journal
Data de publicació
2014-08-19
Volum
107
Número
4
Pàgina inicial
879
Pàgina final
890
DOI
https://doi.org/10.1016/j.bpj.2014.07.015 Obrir en finestra nova
Repositori
http://hdl.handle.net/2117/76951 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0006349514007322 Obrir en finestra nova
Resum
In a previous work, we have shown that a spatially localized transmembrane pH gradient, produced by acid micro-injection near the external side of cardiolipin-containing giant unilamellar vesicles, leads to the formation of tubules that retract after the dissipation of this gradient. These tubules have morphologies similar to mitochondrial cristae. The tubulation effect is attributable to direct phospholipid packing modification in the outer leaflet, that is promoted by protonation of cardiolipi...
Citació
Khalifat, N., Rahimi, M., Bitbol, A., Seigneuret, M., Fournier, J.B., Puff, N., Arroyo, M., Angelova, M. Interplay of packing and flip-flop in local bilayer deformation. How phosphatidylglycerol could rescue mitochondrial function in a cardiolipin-deficient yeast mutant. "Biophysical journal", 19 Agost 2014, núm. 4, p. 879-890.
Paraules clau
CURVATURE, DYNAMICS, GIANT PHOSPHOLIPID-VESICLES, LARGE UNILAMELLAR VESICLES, LIPID PACKING, MEMBRANE DEFORMATION, SACCHAROMYCES-CEREVISIAE, SHAPE CHANGES, TRANSBILAYER TRANSPORT, TRANSMEMBRANE-PH GRADIENTS
Grup de recerca
LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria

Participants

  • Khalifat, Nada  (autor)
  • Rahimi Lenji, Mohammad  (autor)
  • Bitbol, Anne-Florence  (autor)
  • Seigneuret, Michel  (autor)
  • Fournier, Jean-baptiste  (autor)
  • Puff, Nicolas  (autor)
  • Arroyo Balaguer, Marino  (autor)
  • Angelova, Miglena I.  (autor)

Arxius