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A hazard ratio was estimated by a ratio of median survival times, but with considerable uncertainty

Author
Cortes, J.; Gonzalez, J.; Campbell , M.J.; Cobo, E.
Type of activity
Journal article
Journal
Journal of clinical epidemiology
Date of publication
2014-10-01
Volume
67
Number
1
First page
1172
Last page
1177
DOI
https://doi.org/10.1016/j.jclinepi.2014.05.017 Open in new window
URL
http://www.jclinepi.com/article/S0895-4356%2814%2900227-3/abstract Open in new window
Abstract
Objectives: To evaluate the empirical concordance between the hazard ratio (HR) and the median ratio (MR) in survival cancer studies. Study Design and Setting: We selected all cancer survival articles from the New England Journal of Medicine published between 2000 and 2010. The qualitative concordance was estimated by the proportion of measured pairs in which the treatment effects for the MR and HR are in the same direction. The quantitative concordance was assessed through (1) the mean differen...
Keywords
Cancer, Clinical trial, Concordance, Hazard ratio, Median ratio, Survival
Group of research
GNOM - Mathematical Optimization Group
GRBIO - Biostatistics and Bioinformatics Research Group

Participants