Loading...
Loading...

Go to the content (press return)

Improvement in bone mineral density after switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: two-centre randomized pilot study (OsteoTDF study)

Author
Negredo, E.; Domingo, P.; Perez, N.; Gutierrez, M.; Mateo, G.; Puig, J.; Escrig, R.; Echeverria, P.; Bonjoch, A.; Clotet, B.
Type of activity
Journal article
Journal
Journal of antimicrobial chemotherapy
Date of publication
2014-12-01
Volume
69
Number
12
First page
3368
Last page
3371
DOI
https://doi.org/10.1093/jac/dku300 Open in new window
Abstract
Tenofovir has been associated with a decrease in bone mineral density (BMD). However, data on changes in BMD after discontinuing tenofovir are lacking.; We performed a two-centre randomized pilot study in virologically suppressed HIV-infected patients receiving tenofovir with osteopenia/osteoporosis (OsteoTDF study, ClinicalTrials.gov number NCT 01153217). Fifty-four patients were randomly assigned to switch from tenofovir to abacavir (naEuroS=aEuroS26) or to continue with tenofovir (naEuroS=aEu...
Keywords
ANTIRETROVIRAL THERAPY, COHORT, DXA scan, EFAVIRENZ, FRACTURES, HIV, HIV-infected patients, INITIATION, LAMIVUDINE, PREVALENCE, osteoporosis, virologically suppressed
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Negredo Puigmal, Eugènia  (author)
  • Domingo, Pere L.  (author)
  • Perez Alvarez, Nuria  (author)
  • Gutierrez Macià, Maria del Mar  (author)
  • Mateo, Gracia  (author)
  • Puig Batalla, Jordi  (author)
  • Escrig, Roser  (author)
  • Echeverria Liras, Patricia  (author)
  • Bonjoch Badia, Anna  (author)
  • Clotet Sala, Bonaventura  (author)