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Changes in serotonin transporter (5-HTT) gene expression in peripheral blood cells after MDMA intake

Author
Yubero-Lahoz, S.; Kuypers, K.; Ramaekers, J.; Langohr, K.; Farré, M.; De la Torre, R.
Type of activity
Journal article
Journal
Psychopharmacology
Date of publication
2015-06
Volume
232
Number
11
First page
1921
Last page
1929
DOI
https://doi.org/10.1007/s00213-014-3827-4 Open in new window
Abstract
Rationale 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is an amphetamine derivative abused worldwide. Although data report that relatively high doses of MDMA deplete serotonin (5-HT) content and decrease the availability of serotonin transporters (5-HTT), there is no available evi- dence as to the adaptive mechanisms taking place in 5-HTT gene expression following MDMA intake in humans. Objective To evaluate the pharmacological effects of MDMA on 5-HTT gene expression, using peripheral mono...
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Yubero-Lahoz, Samanta  (author)
  • Kuypers, K. P. C.  (author)
  • Ramaekers, J. G.  (author)
  • Langohr, Klaus  (author)
  • Farré, Magí  (author)
  • De la Torre Fornell, Rafael  (author)