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Underwinding and kinking DNA by HMG proteins

Author
Campos, J.Lourdes
Type of activity
Presentation of work at congresses
Name of edition
IV Jornada de Cromatina i Epigenètica
Date of publication
2014
Presentation's date
2015-03-10
Book of congress proceedings
IV Jornada de Cromatina i Epigenètica
First page
5
Last page
5
Abstract
The high mobility group HMG proteins act as architectural proteins that affect cellular functions by modulating chromatin structure and thereby gene expression in eukaryotic cells. HMGB proteins are one of the three members of this family and are defined by their DNA binding motifs, HMGB1 contains two DNA binding domains, box A and box B, which have little sequence specificity but remarkable abilities to underwind and bend DNA. Here we will present the structure of two HMGB1 box A bound to an AT...
Keywords
AT-richDNA, HMG
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

Participants