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Oxidative stress is a central target for physical exercise neuroprotection against pathological brain aging

Author
García-Mesa, Y.; Colie, S.; Corpas, R.; Cristofol, R.; Comellas, F.; Nebreda, A.; Giménez-Llort, L.; Sanfeliu, C.
Type of activity
Journal article
Journal
Journals of gerontology. Series A, biological sciences and medical sciences
Date of publication
2015-02-26
DOI
https://doi.org/10.1093/gerona/glv005 Open in new window
Repository
http://hdl.handle.net/2117/27948 Open in new window
URL
http://biomedgerontology.oxfordjournals.org/content/early/2015/02/22/gerona.glv005 Open in new window
Abstract
Physical exercise is suggested for preventing or delaying senescence and Alzheimer’s disease (AD). We have examined its therapeutic value in the advanced stage of AD-like pathology in 3xTg-AD female mice through voluntary wheel running from 12 to 15 months of age. Mice submitted to exercise showed improved body fitness, immunorejuvenation, improvement of behavior and cognition, and reduced amyloid and tau pathology. Brain tissue analysis of aged 3xTg-AD mice showed high levels of oxidative dam...
Citation
Garcia-Mesa, Y. [et al.]. Oxidative stress is a central target for physical exercise neuroprotection against pathological brain aging. "Journals of gerontology. Series A, biological sciences and medical sciences", 26 Febrer 2015.
Keywords
3xTg-AD mice, Alzheimer’s disease, Amyloid ßPhospho-tau, Behavior tests, Cognition, Oxidative stress, Physical exercise
Group of research
COMBGRAPH - Combinatorics, Graph Theory and Applications

Participants

  • García Mesa, Yoelvis  (author)
  • Colie, Sandra  (author)
  • Corpas, Ruben  (author)
  • Cristofol, Rosa  (author)
  • Comellas Padro, Francesc de Paula  (author)
  • Nebreda, Angel  (author)
  • Giménez-Llort, Lydia  (author)
  • Sanfeliu Pujol, Coral  (author)

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