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Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds

Author
Acosta, F.J.; Alechaga, E.; Subirana, J.; Campos, J.Lourdes
Type of activity
Journal article
Journal
PloS one
Date of publication
2015-03-17
Volume
10
Number
3
Last page
9
DOI
https://doi.org/10.1371/journal.pone.0120241 Open in new window
Repository
http://hdl.handle.net/2117/76646 Open in new window
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120241 Open in new window
URL
http://journals.plos.org/ Open in new window
Abstract
The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)(2), which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformati...
Citation
Acosta, F.J., Subirana, J., Campos, J.Lourdes, Alechaga, E. Structure of the DNA duplex d(ATTAAT)(2) with Hoogsteen hydrogen bonds. "PLoS one", 17 Març 2015, núm. 3.
Keywords
base-pairs, complex, crystal, polymerase-iota, refinement, refmac5, replication, software
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

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