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Frequentist and Bayesian approaches for a joint model for prostate cancer risk and longitudinal prostate-specific antigen data

Author
Serrat, C.; Rué, M.; Armero, C.; Piulachs, X.; Perpiñán, H.; Forte, A.; Páez, Á.; Gómez Melis, Guadalupe
Type of activity
Journal article
Journal
Journal of applied statistics
Date of publication
2015-06-03
Volume
42
Number
6
First page
1223
Last page
1239
DOI
https://doi.org/10.1080/02664763.2014.999032 Open in new window
Project funding
Grup de Recerca en Bioestadística i Bioinformàtica (GRBIO)
Métodos avanzados en estudios de seguimiento: diseño de ensayos clínicos, datos longitudinales y censura en un intervalo
Repository
http://hdl.handle.net/2117/85035 Open in new window
Abstract
The paper describes the use of frequentist and Bayesian shared-parameter joint models of longitudinal measurements of prostate-specific antigen (PSA) and the risk of prostate cancer (PCa). The motivating dataset corresponds to the screening arm of the Spanish branch of the European Randomized Screening for Prostate Cancer study. The results show that PSA is highly associated with the risk of being diagnosed with PCa and that there is an age-varying effect of PSA on PCa risk. Both the frequentist...
Citation
Serrat, C., Rué, M., Armero, C., Piulachs, X., Perpiñán, H., Forte, A., Páez, Á., Gomez, G. Frequentist and Bayesian approaches for a joint model for prostate cancer risk and longitudinal prostate-specific antigen data. "Journal of Applied Statistics", 03 Juny 2015, vol. 42, núm. 6, p. 1223-1239.
Keywords
62N01, 62P10, DISEASE PROGRESSION, FAILURE, FOLLOW-UP, LATENT CLASS MODELS, MORTALITY, PREDICTION, PSA, SURVIVAL, TIME, TO-EVENT DATA, joint models, linear mixed models, prostate cancer screening, relative risk models, shared-parameter models
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Serrat Pie, Carles  (author)
  • Rué, Montserrat  (author)
  • Armero, Carmen  (author)
  • Piulachs Lozada Benavente, Xavier  (author)
  • Perpiñán Fabuel, Hèctor  (author)
  • Forte, Anabel  (author)
  • Páez, Álvaro  (author)
  • Gomez Melis, Guadalupe  (author)

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