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The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression

Author
Olvera, A.; Perez, S.; Ibarrondo, J.; Ganoza, C.; Lama, J.; Lucchetti, A.; Cate, S.; H. Hildebrand, W.; Bernard, N.; Gómez Melis, Guadalupe; Sánchez, J.; Brander, C.
Type of activity
Journal article
Journal
AIDS
Date of publication
2015-03-13
Volume
29
Number
5
First page
507
Last page
517
DOI
https://doi.org/10.1097/QAD.0000000000000574 Open in new window
Project funding
Grup de Recerca en Bioestadística i Bioinformàtica (GRBIO)
Métodos avanzados en estudios de seguimiento: diseño de ensayos clínicos, datos longitudinales y censura en un intervalo
Repository
http://hdl.handle.net/2117/81169 Open in new window
Abstract
Objective: The objective of this study is to identify human leukocyte antigen (HLA) class I and killer-cell immunoglobulin-like receptor (KIR) genotypes associated with different risks for HIV acquisition and HIV disease progression.; Design: A cross-sectional study of a cohort of 468 high-risk individuals (246 HIV-positive and 222 HIV-negative) from outpatient clinics in Lima (Peru).; Methods: The cohort was high-resolution HLA and KIR-typed and analysed for potential differences in single-alle...
Citation
Olvera, A., Pérez, S., Ibarrondo, J., Ganoza, C., Lama, J., Lucchetti, A., Cate, S., H. Hildebrand, W., Bernard, N., Gomez, G., Sánchez, J., Brander, C. The HLA-C*04:01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression. "AIDS", 13 Març 2015, vol. 29, núm. 5, p. 507-517.
Keywords
CD4(+) cell counts, HIV infection, adaptation, aids, associations, hla class-i, human leukocyte antigen class I, immune, killer-cell immunoglobulin-like receptor, kir2ds4, level, risk, t-cell responses, type-1 infection, viral load
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Olvera Van der Stoep, Alex  (author)
  • Perez Alvarez, Susana  (author)
  • Ibarrondo, Javier  (author)
  • Ganoza, Carmela  (author)
  • Lama, Javier R.  (author)
  • Lucchetti, Aldo  (author)
  • Cate, Steven  (author)
  • H. Hildebrand, William  (author)
  • Bernard, Nicole  (author)
  • Gomez Melis, Guadalupe  (author)
  • Sánchez, Jorge  (author)
  • Brander, Christian  (author)

Attachments