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Calcium Alternans is Due to an Order-Disorder Phase Transition in Cardiac Cells

Author
Alvarez-Lacalle, E.; Echebarria, B.; Spalding, J.; Shiferaw, Y.
Type of activity
Journal article
Journal
Physical review letters
Date of publication
2015-03-12
Volume
114
Number
10
DOI
https://doi.org/10.1103/PhysRevLett.114.108101 Open in new window
Project funding
Modelización de dinámica cardiaca a distintas escalas
Repository
http://hdl.handle.net/2117/27817 Open in new window
Abstract
Electromechanical alternans is a beat-to-beat alternation in the strength of contraction of a cardiac cell, which can be caused by an instability of calcium cycling. Using a distributed model of subcellular calcium we show that alternans occurs via an order-disorder phase transition which exhibits critical slowing down and a diverging correlation length. We apply finite size scaling along with a mapping to a stochastic coupled map model, to show that this transition in two dimensions is characte...
Citation
Alvarez-Lacalle, E. [et al.]. Calcium Alternans is Due to an Order-Disorder Phase Transition in Cardiac Cells. "Physical review letters", 12 Març 2015, vol. 114, núm. 10.
Keywords
DYNAMICS, EQUILIBRIUM, LATTICES, MODEL, MYOCYTES
Group of research
BIOCOM-SC - Computational Biology and Complex Systems Group

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