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Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium

Autor
Fraioli, R.; Rechenmacher, F.; Neubauer, S.; Manero, J.; Gil, F.J.; Kessler, H.; Mas-Moruno, C.
Tipus d'activitat
Article en revista
Revista
Colloids and Surfaces B. Biointerfaces
Data de publicació
2015-04-01
Volum
128
Pàgina inicial
191
Pàgina final
200
DOI
https://doi.org/10.1016/j.colsurfb.2014.12.057 Obrir en finestra nova
Projecte finançador
BIBITE
NUEVOS BIOMATERIALES METALICOS BIOFUNCIONALIZADOS PARA APLICACIONES ORTOPEDICAS,
Repositori
http://hdl.handle.net/2117/89018 Obrir en finestra nova
URL
http://www.sciencedirect.com/science/article/pii/S0927776515000168 Obrir en finestra nova
Resum
Interaction between the surface of implants and biological tissues is a key aspect of biomaterials research. Apart from fulfilling the non-toxicity and structural requirements, synthetic materials are asked to direct cell response, offering engineered cues that provide specific instructions to cells. This work explores the functionalization of titanium with integrin-binding peptidomimetics as a novel and powerful strategy to improve the adhesion, proliferation and differentiation of osteoblast-l...
Citació
Fraioli, R., Rechenmacher, F., Neubauer, S., Manero, J., Gil, F.J., Kessler, H., Mas-Moruno, C. Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium. "Colloids and Surfaces B. Biointerfaces", 01 Abril 2015, vol. 128, p. 191-200.
Paraules clau
Functionalization, Integrins, Osteointegration, Peptidomimetics, Titanium, alpha-v-beta-3, behavior, biomaterials, cyclic rgd peptides, fibronectin, implant materials, osteogenic differentiation, saos-2 cells, specificity, surface-chemistry
Grup de recerca
BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
CREB - Centre de Recerca en Enginyeria Biomedica
CRnE - Centre de Recerca en Ciència i Enginyeria Multiescala de Barcelona

Participants

  • Fraioli, Roberta  (autor)
  • Rechenmacher, Florian  (autor)
  • Neubauer, Stefanie  (autor)
  • Manero Planella, Jose M.  (autor)
  • Gil Mur, Francisco Javier  (autor)
  • Kessler, Horst  (autor)
  • Mas Moruno, Carlos  (autor)