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Monotherapy with boosted PIs as an ART simplification strategy in clinical practice

Author
Santos, J.; Llibre, J.M.; Berro, D.; Bravo, I.; Miranda, C.; Perez, S.; Perez, N.; Paredes Deirós, Roger; Clotet, B.; Molto, J.
Type of activity
Journal article
Journal
Journal of antimicrobial chemotherapy
Date of publication
2015-04-01
Volume
70
Number
4
First page
1124
Last page
1129
DOI
https://doi.org/10.1093/jac/dku509 Open in new window
Project funding
Grup de Recerca en Bioestadística i Bioinformàtica (GRBIO)
Métodos avanzados en estudios de seguimiento: diseño de ensayos clínicos, datos longitudinales y censura en un intervalo
URL
http://jac.oxfordjournals.org/content/70/4/1124.long Open in new window
Abstract
Background: Data on the efficacy of simplifying therapy using darunavir/ritonavir and lopinavir/ritonavir monotherapy in clinical practice remain limited.; Methods: A retrospective single-centre study including patients initiating darunavir/ritonavir or lopinavir/ritonavir monotherapy with a plasma HIV-1 viral load (pVL) <50 copies/mL and at least one subsequent follow-up visit. The primary endpoint was the percentage of patients remaining free of virological failure (VF; defined as a confirmed ...
Keywords
NRTI-sparing regimens, darunavir/ritonavir, darunavir/ritonavir monotherapy, hiv-1-infected patients, hiv-infected patients, lopinavir-ritonavir monotherapy, lopinavir/ritonavir monotherapy, maintenance strategy, monet trial, nucleoside analogs, reverse-transcriptase inhibitors, routine clinical setting, tenofovir
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Santos, Jose R.  (author)
  • Llibre, Josep M.  (author)
  • Berrio Galan, Daniel  (author)
  • Bravo, Isabel  (author)
  • Miranda, Cristina  (author)
  • Perez Alvarez, Susana  (author)
  • Perez Alvarez, Nuria  (author)
  • Paredes Deirós, Roger  (author)
  • Clotet Sala, Bonaventura  (author)
  • Molto Marhuenda, Jose  (author)