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Minor groove interactions of AT-rich DNA with dicationic drugs and proteins

Author
Acosta, F.J.; Sanchez-Giraldo,R; Saperas, N.; Millan, C.; Dardonville, C.; De Koning, H.; Campos, J.Lourdes; Churchill, M.
Type of activity
Presentation of work at congresses
Name of edition
VII AUSE Congress and II ALBA User's Meeting
Date of publication
2015
Presentation's date
2015-06
Book of congress proceedings
VII AUSE Congress and II ALBA User's Meeting - 2015
First page
36
Last page
37
URL
https://indico.cells.es/indico/event/24/contribution/92 Open in new window
Abstract
AT-rich DNA is mainly found in non-coding regions in eukaryotes, it represents a large portion of genomes. It is known that some of these non-coding regions play an important role in regulation, transcription and signaling. Some proteins interact with AT-rich DNA as architectural proteins that affect cellular functions by modulating chromatin structure. Moreover DNA of several pathogens is very rich in AT base pairs. Typical examples include the malaria parasite Plasmodium falciparum which has 8...
Group of research
CEBIM - Molecular Biotechnology Centre
MACROM - Crystallography, Structure and Function of Biological Macromolecules

Participants

  • Acosta Reyes, Francisco Javier  (author and speaker )
  • Sanchez-Giraldo, Raquel  (author and speaker )
  • Saperas Plana, Nuria  (author and speaker )
  • Millan Elias, Cinthia Raquel  (author and speaker )
  • Dardonville, Cristophe  (author and speaker )
  • De Koning, harry p.  (author and speaker )
  • Campos Lopez, Josefa de Lourdes  (author and speaker )
  • Churchill, Mair  (author and speaker )