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Biophotonics and hyperspectral imaging technology applied to visual health and skin cancer research

Total activity: 3
Type of activity
Competitive project
Funding entity
Funding entity code
181.500,00 €
Start date
End date
BIOHYP aims at developing new methods and diagnostic tools as well as original and feasible solutions applicable to visual health and
skin cancer diagnosis based on biophotonics and visual optics along with hyperspectral imaging technology. New lines of research with
ambitious objectives that can contribute to the development of new scientific and technological knowledge are proposed in this project.
In the field of biophotonics and visual optics, BIOHYP aims at developing new systems and proposing novel methods for the full
characterization of intraocular lenses used to correct presbyopia by means of binocular and open-field optical setups capable of evaluating
both the objective and subjective visual performance prior to and after surgery. This might lead to a marked improvement of the
performance of intraocular lenses used in ophthalmology. The project also includes the development of a new system for the individual
assessment of scattering associated to the cornea and the lens based on the light diffusely reflected back by several ocular structures
such as the cornea, iris and lens. BIOHYP aims at proposing robust parameters for the scattering assessment useful for the detection and
follow-up of corneal diseases, cataracts and eyes with dry-eye symptom. On the other hand, BIOHYP aims at using fully autonomous and
automatic registers of the eye movements and pupil diameter to propose new methods for diagnosis of the visual function and visual
therapy, much faster and cheaper than the methods used at present. This can therefore have a strong social impact visual therapy
treatments approaching to everyone.
In the field of hyperspectral imaging technology, BIOHYP aims at developing a novel expanded hyperspectral imaging system covering the
visible and the infrared ranges (up to 5 micrometers) with a high-precision tunable luminaire based on light-emitting diodes (LED), as well
as proposing new algorithms based on this system for the earlier detection and follow-up of skin cancer lesions, especially melanoma
which is the most aggressive one. BIOHYP will also make use of such a technology to develop a novel fast and expanded system covering
the visible and infrared (up to 2.5 micrometers) based on LEDs but also tunable filters of liquid crystal technology for the dynamic recording
of the ocular fundus. This will enable detecting and following-up ocular diseases such as retinopathy, age-related macular degeneration,
and glaucoma by means of new diagnostic tools. Finally, the project aims at developing a TeraHertz-based monitoring system and new
algorithms and robust parameters for the characterization of contact and intraocular lens materials and corneal hydration, making use of
this novel technology. These tools may assist in the diagnosis and treatment of corneal alterations such as dystrophies, degenerations,
injuries, and corneal graft rejection as they produce marked changes in the water content of the cornea. If sufficient sensitivity can be
achieved, THz sensing may also be helpful for tear film evaluation in eyes with dry-eye symptom.
The outcome of BIOHYP will not only benefit the visual health and the skin cancer sectors but will also provide novel and valuable tools
based on photonic and optical technologies suitable to be transferred to industry for innovation.
Adm. Estat
Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016
Call year
Funcding program
Programa Estatal de I+D+i Orientada a los Retos de la Sociedad
Funding call
Retos de Investigación: Proyectos de I+D+i
Grant institution
Gobierno De España. Ministerio De Economía Y Competitividad, Mineco


Scientific and technological production

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