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Comparison of two different strategies of treatment with zoledronate in HIV-infected patients with low bone mineral density: single dose versus two doses in 2 yearseral density: single dose versus two doses in 2 years

Author
Negredo, E.; Bonjoch, A.; Perez, N.; Ornelas, A.; Puig, J.; Herrero, C.; Estany, C.; del Rio, L.; Di Gregorio, S.; Echeverria, P.; Clotet, B.
Type of activity
Journal article
Journal
HIV medicine
Date of publication
2015-08-01
Volume
16
Number
7
First page
441
Last page
448
DOI
https://doi.org/10.1111/hiv.12260 Open in new window
URL
http://onlinelibrary.wiley.com/doi/10.1111/hiv.12260/full Open in new window
Abstract
Objectives: Given the need for easily managed treatment of osteoporosis in HIV-infected patients, we evaluated the efficacy and tolerability of two doses of zoledronate, by comparing three groups of patients: those with annual administration, those with biennial administration (one dose in 2 years) and a control group with no administration of zoledronate.; MethodsWe randomized (2:1) 31 patients on antiretroviral therapy with low bone mineral density (BMD) to zoledronate (5mg administered intrav...
Keywords
HIV, acid, alendronate, annual administration, antiretroviral therapy, biennial administration, bisphosphonate, bone mineral density, clinical fractures, dual-energy X-ray absorptiometry scan, high prevalence, osteopenia, osteopenia/osteoporosis, osteoporosis, postmenopausal osteoporosis, risk, vitamin-d, zoledronate
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Negredo Puigmal, Eugènia  (author)
  • Bonjoch Badia, Anna  (author)
  • Perez Alvarez, Nuria  (author)
  • Ornelas Vargas, Arelly  (author)
  • Puig Domingo, Jordi  (author)
  • Herrero, C.  (author)
  • Estany Quera, Carla  (author)
  • del Rio, Luis  (author)
  • Di Gregorio, Silvana  (author)
  • Echeverria Liras, Patricia  (author)
  • Clotet Sala, Bonaventura  (author)