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Switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: changes in bone turnover markers and circulating sclerostin levels

Author
Negredo, E.; Díez-Perez, A.; Bonjoch, A.; Domingo, P.; Perez, N.; Gutierrez, M.; Mateo, G.; Puig, J.; Echeverria, P.; Escrig, R.; Clotet, B.
Type of activity
Journal article
Journal
Journal of antimicrobial chemotherapy
Date of publication
2015-07-01
Volume
70
Number
7
First page
2104
Last page
2107
DOI
https://doi.org/10.1093/jac/dkv063 Open in new window
URL
http://jac.oxfordjournals.org/content/70/7/2104 Open in new window
Abstract
Background: Tenofovir is involved in accelerated bone mineral density (BMD) loss.; Methods: We recently published a hip BMD improvement at week 48 [+2.1% (95% CI: -0.6, 4.7) (P = 0.043)] in HIV-infected patients with osteopenia/osteoporosis randomized to switch from tenofovir to abacavir (n = 26), although without reaching statistical significance compared with those who maintained tenofovir (n = 28). Here, we present changes at week 48 in bone markers [C-terminal telopeptide of collagen type 1 ...
Keywords
HIV-infected patients, antiretroviral-naive, bmp antagonist, bone markers, efavirenz, fractures, metabolism, osteoporosis, osteoprotegerin, rankl, serum sclerostin, skeleton, women
Group of research
GRBIO - Biostatistics and Bioinformatics Research Group

Participants

  • Negredo Puigmal, Eugènia  (author)
  • Díez Pérez, Adolfo  (author)
  • Bonjoch Badia, Anna  (author)
  • Domingo, Pere L.  (author)
  • Perez Alvarez, Nuria  (author)
  • Gutierrez Macià, Maria del Mar  (author)
  • Mateo, Gracia  (author)
  • Puig Domingo, Jordi  (author)
  • Echeverria Liras, Patricia  (author)
  • Escrig, Roser  (author)
  • Clotet Sala, Bonaventura  (author)