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Exact inference for Hardy-Weinberg proportions with missing genotypes: single and multiple imputation

Author
Graffelman, J.; Nelson, S.; Gogarten, S.; Weir, B.
Type of activity
Journal article
Journal
G3-Genes Genomes Genetics
Date of publication
2015-09-15
Volume
5
Number
11
First page
2365
Last page
2373
DOI
https://doi.org/10.1534/g3.115.022111 Open in new window
Repository
http://hdl.handle.net/2117/82666 Open in new window
Abstract
This paper addresses the issue of exact-test based statistical inference for Hardy-Weinberg equilibrium in the presence of missing genotype data. Missing genotypes often are discarded when markers are tested for Hardy-Weinberg equilibrium, which can lead to bias in the statistical inference about equilibrium. Single and multiple imputation can improve inference on equilibrium. We develop tests for equilibrium in the presence of missingness by using both inbreeding coefficients (or, equivalently,...
Citation
Graffelman, J., Nelson, S., Gogarten, S., Weir, B. Exact inference for Hardy-Weinberg proportions with missing genotypes: single and multiple imputation. "G3-Genes Genomes Genetics", 15 Setembre 2015, vol. 5, núm. 11, p. 2365-2373.
Group of research
COSDA-UPC - COmpositional and Spatial Data Analysis

Participants

  • Graffelman, Jan  (author)
  • Nelson, S.  (author)
  • Gogarten, S.M.  (author)
  • Weir, B.S.  (author)

Attachments